Publications

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Antibody Discovery and IgG Profiling

Cell Line Development

Zuly Peralta 6/8/26 Zuly Peralta 6/8/26

Cell-Cell-Seq resolves contact-associated NK cell activation in defined tumor cell dyads

Jesse Liang, Devon Shao, Dino Di Carlo, Joseph de Rutte

bioRxiv, June 2026

Joseph de Rutte 5/1/26 Joseph de Rutte 5/1/26

SEC-seq reveals translation-focused metabolic strategies for high IgG productivity in clonal CHO cells

Jasmine Tat, Fides D. Lay, Jennitte Stevens, Nathan E. Lewis

bioRxiv, April 2026

Joseph de Rutte 5/1/26 Joseph de Rutte 5/1/26

Universal Nanovial Screening Enables Functional Discovery of Metabolite-Reactive T‑Cell Receptors for Cancer Therapy

Citradewi Soemardy, Yan-Ruide Li, Yichen Zhu, Xinyuan Shen, Lili Yang, Dino Di Carlo

ACS Nano, April 2026

Joseph de Rutte 7/5/25 Joseph de Rutte 7/5/25

Screening of a pooled library of chimeric antigen receptor T cells based on secretory function

Citradewi Soemardy, Anna Mei, Rocio Castellanos-Rueda, Nikol Garcia Espinoza, Monika Kizerwetter, Jamie B Spangler, Sai T Reddy, Dino Di Carlo

bioRxiv, July 2025

Joseph de Rutte 6/20/25 Joseph de Rutte 6/20/25

Specific Stimulation and Multiplex Secretion Analysis of T Cells Using a Suspendable Hydrogel Platform Enables Immunophenotyping at the Single-Cell Scale

Monika Kizerwetter, Doyeon Koo, Citradewi Soemardy, Théo Nass, Joseph Choy, Ariel Isser, Nikol Garcia Espinoza, Aleksander Geske, Xinzhong Dong, Jonathan P. Schneck, Dino Di Carlo, Jamie B. Spangler

ACS Nano, June 2025

Joseph de Rutte 5/22/25 Joseph de Rutte 5/22/25

Linking Epitope-Specific T-Cell Receptors to IFNγ Secretion Using Nanovial Technology

Jet van den Dijssel, Tejas Menon, Hayley A. McQuilten, Oliver Eltherington, Alexis Gonzalez, Sevana Baghdasarian, Citradewi Soemardy, Dino Di Carlo, Klaas P.J.M. van Gisbergen, Anja ten Brinke, Carolien E. van de Sandt

European Journal of Immunology, May 2025

Joseph de Rutte 8/20/24 Joseph de Rutte 8/20/24

Function-first Discovery of High Affinity Monoclonal Antibodies Using Nanovial-Based Plasma B Cell Screening

Dilip Challa, Joseph de Rutte, Cassady Konu, Shreya Udani, Jesse Liang, Patrick J Krohl, Ronald Rondon, Kent Bondensgaard, Dino Di Carlo, Jennifer Watkins-Yoon

bioRxiv, August 2024

Joseph de Rutte 6/13/24 Joseph de Rutte 6/13/24

Optimizing Cell Therapy by Sorting Cells with High Extracellular Vesicle Secretion

Doyeon Koo, Xiao Cheng, Shreya Udani, Sevana Baghdasarian, Dashuai Zhu, Junlang Li, Brian Hall, Natalie Tsubamoto, Shiqi Hu, Jina Ko, Ke Cheng & Dino Di Carlo

Nature Communications, 2024

Joseph de Rutte 4/16/24 Joseph de Rutte 4/16/24

Defining T cell receptor repertoires using nanovial-based binding and functional screening

Doyeon Koo, Zhiyuan Mao, Robert Dimatteo, Miyako Noguchi, Natalie Tsubamoto, Jami McLaughlin, Wendy Tran, Sohyung Lee, Donghui Cheng, Joseph de Rutte, Giselle Burton Sojo, Owen N. Witte & Dino Di Carlo

PNAS, March 2024

Joseph de Rutte 1/10/24 Joseph de Rutte 1/10/24

Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq

Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath & Dino Di Carlo

Nature Nanotechnology, December 2023

Joseph de Rutte 6/15/23 Joseph de Rutte 6/15/23

SEC-seq: Association of molecular signatures with antibody secretion in thousands of single human plasma cells

Rene Yu-Hong Cheng, Joseph de Rutte, Cade Ellis Ito, Andee R. Ott, Lucie Bosler, Wei-Ying Kuo, Jesse Liang, Brian E Hall, David J Rawlings, Dino Di Carlo, Richard G. James

Nature Communications, June 2023