Publications

Featured Articles

Functionalizing Hydrogel Nanovials with Vesicles Mimicking Antigen-Presenting Vesicles and Cancer Exosomes Improves T Cell Capture and Activation.

Blade A. Olson, Michael Mellody, Citradewi Soemardy, Zhiyuan Mao, Anna Mei, Katie Lippert, Magnus A. G. Hoffmann, Dino Di Carlo, Stephen L. Mayo

ACS Nano, July 2026

Mapping and engineering the human cell–cell interactome

Dino Di Carlo, Leonardo Morsut, Megan L. McCain, Heather J. Wright, Mohamad Abedi, Sean A. Yamada-Hunter, Jason Z. Zhang, Keriann Backus, Eunji Chung, Yingxiao Wang, Thomas A. Rando, Long Cai, Matt Thomson, Michael B. Elowitz, John K. Lee & Owen Witte

Nature Biotechnology, June 2026

Cell-Cell-Seq resolves contact-associated NK cell activation in defined tumor cell dyads

Jesse Liang, Devon Shao, Dino Di Carlo, Joseph de Rutte

bioRxiv, June 2026

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Area of Interest

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Antibody Discovery and IgG Profiling

Cell Line Development

Joseph de Rutte 8/3/26 Joseph de Rutte 8/3/26

Functionalizing Hydrogel Nanovials with Vesicles Mimicking Antigen-Presenting Vesicles and Cancer Exosomes Improves T Cell Capture and Activation.

Blade A. Olson, Michael Mellody, Citradewi Soemardy, Zhiyuan Mao, Anna Mei, Katie Lippert, Magnus A. G. Hoffmann, Dino Di Carlo, Stephen L. Mayo

ACS Nano, July 2026

Joseph de Rutte 3/11/26 Joseph de Rutte 3/11/26

Systematic mapping of emergent transcriptional states in interacting single-cell dyads by Cell-Cell-seq

Sevana Baghdasarian, Qingyang Wang, Justin Langerman, Zhiyuan Mao, Heather Wright, Caitlin Gee, Donghui Cheng, Jami McLaughlin, John K. Lee, Xiaojing Chen, K. Christopher Garcia, Jingyi Jessica Li, Owen N. Witte, Kathrin Plath, Dino Di Carlo

bioRxiv, February 2026

Joseph de Rutte 2/20/25 Joseph de Rutte 2/20/25

Linking Single-Cell Transcriptomes with Secretion Using SEC-seq

Justin Langerman, Sevana Baghdasarian, Rene Yu-Hong Cheng, Richard G. James, Kathrin Plath & Dino Di Carlo

Nature Protocols, February 2025

Joseph de Rutte 1/27/25 Joseph de Rutte 1/27/25

Multi-reactive Hydrogel Nanovials for Temporal Control of Secretion Capture from Antibody-Secreting Cells

Michael Mellody, Yuta Nakagawa, Richard James and Dino Di Carlo

Lab on a Chip, January 2025

Joseph de Rutte 5/29/24 Joseph de Rutte 5/29/24

On the Compatibility of Single-Cell Microcarriers (Nanovials) with Microfluidic Impedance Cytometry

Cristian Brandi, Adele De Ninno, Filippo Ruggiero, Emanuele Limiti, Franca Abbruzzese, Marcella Trombetta, Alberto Rainer, Paolo Bisegna, and Federica Caselli.

Lab on a Chip, May 2024

Joseph de Rutte 1/10/24 Joseph de Rutte 1/10/24

Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq

Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath & Dino Di Carlo

Nature Nanotechnology, December 2023

Joseph de Rutte 6/15/23 Joseph de Rutte 6/15/23

SEC-seq: Association of molecular signatures with antibody secretion in thousands of single human plasma cells

Rene Yu-Hong Cheng, Joseph de Rutte, Cade Ellis Ito, Andee R. Ott, Lucie Bosler, Wei-Ying Kuo, Jesse Liang, Brian E Hall, David J Rawlings, Dino Di Carlo, Richard G. James

Nature Communications, June 2023

Joseph de Rutte 3/23/22 Joseph de Rutte 3/23/22

Suspendable Hydrogel Nanovials for Massively Parallel Single-Cell Functional Analysis and Sorting

Joseph de Rutte, Robert Dimatteo, Maani M. Archang, Mark van Zee, Doyeon Koo, Sohyung Lee, Allison C. Sharrow, Patrick J. Krohl, Michael Mellody, Sheldon Zhu, James V. Eichenbaum, Monika Kizerwetter, Shreya Udani, Kyung Ha, Richard C. Willson, Andrea L. Bertozzi, Jamie B. Spangler, Robert Damoiseaux, and Dino Di Carlo

ACS Nano, March 2022

Joseph de Rutte 11/1/21 Joseph de Rutte 11/1/21

Scalable Fabrication and Use of 3D Structured Microparticles Spatially Functionalized with Biomolecules

Sohyung Lee, Joseph de Rutte, Robert Dimatteo, Doyeon Koo, and Dino Di Carlo

ACS Nano, November 2022