Publications
Functionalizing Hydrogel Nanovials with Vesicles Mimicking Antigen-Presenting Vesicles and Cancer Exosomes Improves T Cell Capture and Activation.
Blade A. Olson, Michael Mellody, Citradewi Soemardy, Zhiyuan Mao, Anna Mei, Katie Lippert, Magnus A. G. Hoffmann, Dino Di Carlo, Stephen L. Mayo
ACS Nano, July 2026
Mapping and engineering the human cell–cell interactome
Dino Di Carlo, Leonardo Morsut, Megan L. McCain, Heather J. Wright, Mohamad Abedi, Sean A. Yamada-Hunter, Jason Z. Zhang, Keriann Backus, Eunji Chung, Yingxiao Wang, Thomas A. Rando, Long Cai, Matt Thomson, Michael B. Elowitz, John K. Lee & Owen Witte
Nature Biotechnology, June 2026
Cell-Cell-Seq resolves contact-associated NK cell activation in defined tumor cell dyads
Jesse Liang, Devon Shao, Dino Di Carlo, Joseph de Rutte
bioRxiv, June 2026
Systematic mapping of emergent transcriptional states in interacting single-cell dyads by Cell-Cell-seq
Sevana Baghdasarian, Qingyang Wang, Justin Langerman, Zhiyuan Mao, Heather Wright, Caitlin Gee, Donghui Cheng, Jami McLaughlin, John K. Lee, Xiaojing Chen, K. Christopher Garcia, Jingyi Jessica Li, Owen N. Witte, Kathrin Plath, Dino Di Carlo
bioRxiv, February 2026
Enhancing large particle recovery in high-throughput functional cell sorting through ΔBOP optimization
Naohisa Sakamoto, Eikichi Shibata, Mitsuo Yoshimura, Haruto Namura, Yudai Yanashita, Shin Masuhara, Yusuke Uehara, Kenji Yamane, Hiroto Kasai, Motohiro Furuki & Yoshiharu Hayashi
Scientific Reports, December 2025
Sealable capped nanovials for high-throughput screening of cell growth and function
Michael Mellody, Yuta Nakagawa, Alyssa Arnheim, Lily Shang, Catherine Soo, Natalie Tsubamoto, Sarah Taylor, Sumedha Shastry, Wesley Luk, Ian Morales, Richard James, Di Carlo
bioRxiv, June 2025
Linking Single-Cell Transcriptomes with Secretion Using SEC-seq
Justin Langerman, Sevana Baghdasarian, Rene Yu-Hong Cheng, Richard G. James, Kathrin Plath & Dino Di Carlo
Nature Protocols, February 2025
Lab on a Particle Technologies
Rajesh Ghosh, Alyssa Arnheim, Mark van Zee, Lily Shang, Citradewi Soemardy, Rui-Chian Tang, Michael Mellody, Sevana Baghdasarian, Edwin Sanchez Ochoa, Shun Ye, Siyu Chen, Cayden Williamson, Amrith Karunaratne, and Dino Di Carlo
Analytical Chemistry, May 2024
On the Compatibility of Single-Cell Microcarriers (Nanovials) with Microfluidic Impedance Cytometry
Cristian Brandi, Adele De Ninno, Filippo Ruggiero, Emanuele Limiti, Franca Abbruzzese, Marcella Trombetta, Alberto Rainer, Paolo Bisegna, and Federica Caselli.
Lab on a Chip, May 2024
Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq
Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath & Dino Di Carlo
Nature Nanotechnology, December 2023
Suspendable Hydrogel Nanovials for Massively Parallel Single-Cell Functional Analysis and Sorting
Joseph de Rutte, Robert Dimatteo, Maani M. Archang, Mark van Zee, Doyeon Koo, Sohyung Lee, Allison C. Sharrow, Patrick J. Krohl, Michael Mellody, Sheldon Zhu, James V. Eichenbaum, Monika Kizerwetter, Shreya Udani, Kyung Ha, Richard C. Willson, Andrea L. Bertozzi, Jamie B. Spangler, Robert Damoiseaux, and Dino Di Carlo
ACS Nano, March 2022
Scalable Fabrication and Use of 3D Structured Microparticles Spatially Functionalized with Biomolecules
Sohyung Lee, Joseph de Rutte, Robert Dimatteo, Doyeon Koo, and Dino Di Carlo
ACS Nano, November 2022
Sorting Single‐Cell Microcarriers Using Commercial Flow Cytometers
Joseph de Rutte, Robert Dimatte, Sheldon Zhu, Maani M. Archang, Dino Di Carlo
SLAS Technology, October 2021