Publications

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Antibody Discovery and IgG Profiling

Cell Line Development

Joseph de Rutte 8/3/26 Joseph de Rutte 8/3/26

Functionalizing Hydrogel Nanovials with Vesicles Mimicking Antigen-Presenting Vesicles and Cancer Exosomes Improves T Cell Capture and Activation.

Blade A. Olson, Michael Mellody, Citradewi Soemardy, Zhiyuan Mao, Anna Mei, Katie Lippert, Magnus A. G. Hoffmann, Dino Di Carlo, Stephen L. Mayo

ACS Nano, July 2026

Zuly Peralta 6/8/26 Zuly Peralta 6/8/26

Cell-Cell-Seq resolves contact-associated NK cell activation in defined tumor cell dyads

Jesse Liang, Devon Shao, Dino Di Carlo, Joseph de Rutte

bioRxiv, June 2026

Joseph de Rutte 5/1/26 Joseph de Rutte 5/1/26

Universal Nanovial Screening Enables Functional Discovery of Metabolite-Reactive T‑Cell Receptors for Cancer Therapy

Citradewi Soemardy, Yan-Ruide Li, Yichen Zhu, Xinyuan Shen, Lili Yang, Dino Di Carlo

ACS Nano, April 2026

Joseph de Rutte 7/5/25 Joseph de Rutte 7/5/25

Screening of a pooled library of chimeric antigen receptor T cells based on secretory function

Citradewi Soemardy, Anna Mei, Rocio Castellanos-Rueda, Nikol Garcia Espinoza, Monika Kizerwetter, Jamie B Spangler, Sai T Reddy, Dino Di Carlo

bioRxiv, July 2025

Joseph de Rutte 6/20/25 Joseph de Rutte 6/20/25

Specific Stimulation and Multiplex Secretion Analysis of T Cells Using a Suspendable Hydrogel Platform Enables Immunophenotyping at the Single-Cell Scale

Monika Kizerwetter, Doyeon Koo, Citradewi Soemardy, Théo Nass, Joseph Choy, Ariel Isser, Nikol Garcia Espinoza, Aleksander Geske, Xinzhong Dong, Jonathan P. Schneck, Dino Di Carlo, Jamie B. Spangler

ACS Nano, June 2025

Joseph de Rutte 6/28/24 Joseph de Rutte 6/28/24

Lab on a Particle Technologies

Rajesh Ghosh, Alyssa Arnheim, Mark van Zee, Lily Shang, Citradewi Soemardy, Rui-Chian Tang, Michael Mellody, Sevana Baghdasarian, Edwin Sanchez Ochoa, Shun Ye, Siyu Chen, Cayden Williamson, Amrith Karunaratne, and Dino Di Carlo

Analytical Chemistry, May 2024

Joseph de Rutte 6/13/24 Joseph de Rutte 6/13/24

Optimizing Cell Therapy by Sorting Cells with High Extracellular Vesicle Secretion

Doyeon Koo, Xiao Cheng, Shreya Udani, Sevana Baghdasarian, Dashuai Zhu, Junlang Li, Brian Hall, Natalie Tsubamoto, Shiqi Hu, Jina Ko, Ke Cheng & Dino Di Carlo

Nature Communications, 2024

Joseph de Rutte 4/16/24 Joseph de Rutte 4/16/24

Defining T cell receptor repertoires using nanovial-based binding and functional screening

Doyeon Koo, Zhiyuan Mao, Robert Dimatteo, Miyako Noguchi, Natalie Tsubamoto, Jami McLaughlin, Wendy Tran, Sohyung Lee, Donghui Cheng, Joseph de Rutte, Giselle Burton Sojo, Owen N. Witte & Dino Di Carlo

PNAS, March 2024

Joseph de Rutte 1/10/24 Joseph de Rutte 1/10/24

Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq

Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath & Dino Di Carlo

Nature Nanotechnology, December 2023

Joseph de Rutte 7/22/22 Joseph de Rutte 7/22/22

Single-cell sorting based on secreted products for functionally defined cell therapies

Hiromi Miwa, Robert Dimatteo, Joseph de Rutte, Rajesh Ghosh & Dino Di Carlo

Nature Microsystems & Nanoengineering, July 2022

Joseph de Rutte 10/9/21 Joseph de Rutte 10/9/21

Sorting Single‐Cell Microcarriers Using Commercial Flow Cytometers

Joseph de Rutte, Robert Dimatte, Sheldon Zhu, Maani M. Archang, Dino Di Carlo

SLAS Technology, October 2021