Publications

Featured Articles

Functionalizing Hydrogel Nanovials with Vesicles Mimicking Antigen-Presenting Vesicles and Cancer Exosomes Improves T Cell Capture and Activation.

Blade A. Olson, Michael Mellody, Citradewi Soemardy, Zhiyuan Mao, Anna Mei, Katie Lippert, Magnus A. G. Hoffmann, Dino Di Carlo, Stephen L. Mayo

ACS Nano, July 2026

Mapping and engineering the human cell–cell interactome

Dino Di Carlo, Leonardo Morsut, Megan L. McCain, Heather J. Wright, Mohamad Abedi, Sean A. Yamada-Hunter, Jason Z. Zhang, Keriann Backus, Eunji Chung, Yingxiao Wang, Thomas A. Rando, Long Cai, Matt Thomson, Michael B. Elowitz, John K. Lee & Owen Witte

Nature Biotechnology, June 2026

Cell-Cell-Seq resolves contact-associated NK cell activation in defined tumor cell dyads

Jesse Liang, Devon Shao, Dino Di Carlo, Joseph de Rutte

bioRxiv, June 2026

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Antibody Discovery and IgG Profiling

Cell Line Development

Joseph de Rutte 5/1/26 Joseph de Rutte 5/1/26

SEC-seq reveals translation-focused metabolic strategies for high IgG productivity in clonal CHO cells

Jasmine Tat, Fides D. Lay, Jennitte Stevens, Nathan E. Lewis

bioRxiv, April 2026

Joseph de Rutte 2/20/25 Joseph de Rutte 2/20/25

Linking Single-Cell Transcriptomes with Secretion Using SEC-seq

Justin Langerman, Sevana Baghdasarian, Rene Yu-Hong Cheng, Richard G. James, Kathrin Plath & Dino Di Carlo

Nature Protocols, February 2025

Joseph de Rutte 1/10/24 Joseph de Rutte 1/10/24

Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq

Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath & Dino Di Carlo

Nature Nanotechnology, December 2023