https://www.partillion.com/news daily 0.75 2026-04-02 https://www.partillion.com/news/key-takeaways-from-the-2026-cell-cell-symposium monthly 0.5 2026-04-02 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/2244279e-02d4-4a39-a673-e58df92ea291/Untitled+design+%2813%29.png News - A New Framework for Understanding Biology: Key Takeaways from the 2026 Cell-Cell Symposium - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/e2ef963c-3ed0-4b56-8d98-1b12c5fbc1ff/IMG_3448.jpg News - A New Framework for Understanding Biology: Key Takeaways from the 2026 Cell-Cell Symposium That perspective was reflected in the structure of the meeting itself, which followed a clear arc: measure, model, and engineer cell-cell interactions. This vision came into sharp focus during discussions around the Billion Cell × Cell Project, which aims to build scalable, standardized datasets of cell-cell interactions and create the foundation for more predictive models of multicellular biology. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/d2e4c8c5-0d72-47ae-b097-95c77f23ec58/The+Full+Story.png News - A New Framework for Understanding Biology: Key Takeaways from the 2026 Cell-Cell Symposium https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/faaa8016-7be0-45b8-832d-ae8788ae6683/mapstomechanism.png News - A New Framework for Understanding Biology: Key Takeaways from the 2026 Cell-Cell Symposium - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/e1eaf84e-c478-4769-9e41-5a68278644f7/Chen-NK+model.webp News - A New Framework for Understanding Biology: Key Takeaways from the 2026 Cell-Cell Symposium - A full session of the symposium was devoted to modeling cell-cell systems across scales, underscoring how central computational frameworks have become in this emerging space. Back at MD Anderson, Ken Chen used virtual-cell approaches to interpret response and resistance in NK-cell therapy, arguing for interpretable models grounded in real functional data. USC professor Stacey Finley presented image-initialized agent-based models of metastatic breast cancer, showing how immune recruitment and spatial organization can shape whether tumors progress or remain controlled. And UCLA professor Alex Hoffmann explored how intracellular signaling dynamics encode information and how that information is transmitted between cells during inflammation. These were not presented as abstract computational exercises. Instead, modeling emerged as a bridge between observation and intervention — a way to move from complex interaction data toward mechanism, prediction, and eventually therapeutic insight. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/9c3e29df-84f1-4afe-9a9a-094a58f4a385/EngineeredCellCommunication.png News - A New Framework for Understanding Biology: Key Takeaways from the 2026 Cell-Cell Symposium One of the most exciting themes of the meeting was the idea that the field is no longer just engineering cells — it is beginning to engineer interactions. Leonardo Morsut of USC showed how synthetic signaling systems such as synNotch circuits can be used to control multicellular patterning, morphogenesis, and differentiation. His examples ranged from contact-dependent edge detection to reaction-diffusion-like patterns and engineered organizers that improved kidney organoid patterning. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/58a448ed-3413-404b-83fc-b34545128957/WhatIsCellCellSeq.png News - A New Framework for Understanding Biology: Key Takeaways from the 2026 Cell-Cell Symposium - Be Part of The Next Era of Biology Measure time-resolved functional responses in defined cell pairs Uncover interaction-induced gene expression programs Power virtual cell models with cell-cell context https://www.partillion.com/news/painting-a-picture-immunology-2024 monthly 0.5 2026-03-30 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/9ceb49d5-6cf3-409c-a3ae-002abfa75a18/Persistence+of+T+cells+2.jpg News - Painting a Picture of Trends at Immunology 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/855ae497-9076-4422-a82c-4e54e2b81288/Types+of+T+%281%29.png News - Painting a Picture of Trends at Immunology 2024 All of these options have their strengths and challenges, but since all three are engineered cells, they must be expanded or edited ex vivo, before being infused into the patient. After infusion, the engineered cells must remain alive, and active in order to exert their anti-tumor effects. Therapeutic success in many studies has been correlated with increased persistence of the cell product, so it follows that this would be a major area of study, not just for the development of new therapies, but for the improvement of existing ones as well. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/17b798c0-af01-42b7-a483-57f846a09dfe/Last+Supper+of+Metabolites.png News - Painting a Picture of Trends at Immunology 2024 During the President’s Symposium, Dr. Susan Kaech from the Salk Institute shared a compelling story featuring bile acids and their effect on T-cells. As opposed to tissue resident cells which develop within the tissue they live in, T-cells are introduced to an organ completely foreign to them, necessitating the need to adapt. Since tumors arise from a variety of organs, Kaech impassioned the importance of considering how the tumor tissue of origin can affect the immune response, particularly the different metabolic activities of those tissues. “Signal four” Kaech added to the traditional T-cell activation paradigm of signal one antigen, signal two co-stimulation, signal three cytokines, “is nutrients.” In models of colorectal cancer (MC38) and melanoma (B16), Kaech’s lab studied the metabolomics of the tumor interstitial fluid, affectionately termed “tumor juice”, to probe the metabolic exhaustion that occurs in tumors in the hopes of determining if there are metabolomic checkpoints or immunosuppressive metabolites. This exhaustion can change the nutrient availability for tumor infiltrating T-cells, which can affect their function. Compared to serum, oxidized lipids and polyunsaturated fatty acids (PUFA) including arachidonic acid were more abundant in the tumor juice. As T-cells become exhausted they upregulate EP2 and EP4 to be more responsive to PGE2, a metabolite of arachidonic acid. This can lead to suppression of function and cell death, ultimately causing reduced tumor persistence. These exhausted T-cells also upregulate CD36 which binds to oxidized lipids, inducing ferroptosis (an iron-dependent cell death). https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/2a5b7adb-a0f3-44c9-b6ac-872bcbe149cd/nihms-1711911-f0008.jpg News - Painting a Picture of Trends at Immunology 2024 Lipid buildup in the tumor microenvironment impacts immune cells. Xu et al. (2021) reveal that CD8+ T cells adapt by upregulating CD36, causing oxidized lipid accumulation and T cell dysfunction. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/edec828c-14f3-4baf-9242-399a4fa6ac1b/adams+immune+system.png News - Painting a Picture of Trends at Immunology 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/1713290891521-G6P7BPVA6B0KRD2XUC1U/PNAS.jpg News - Painting a Picture of Trends at Immunology 2024 - Learn How Researchers Are Using Nanovials To Interrogate Immune Cells Visit the Publications Page https://www.partillion.com/news/top-trends-in-immunotherapy-festival-of-biologics-2023-recap monthly 0.5 2024-05-29 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/ad176c16-e064-447b-86f0-6168e4eb34ce/IMG_4783.jpg News - Top Trends in Immunotherapy – Festival of Biologics 2023 Recap https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/c23da23f-93e2-45f6-8f7b-447cba6b40b8/IMG_4782.jpg News - Top Trends in Immunotherapy – Festival of Biologics 2023 Recap There was much debate on the benefits and risks or MsAbs in the Keynote panel discussion, “Engineering Next Generation Therapeutics – the future of biologic development”. Louis Boon, CSO of JJP Biologics, argued that it is better to understand the mechanisms behind immune evasion or lack of efficacy for certain patients and focus on finding new biomarkers versus making more complex systems. For example, monoclonal IgG4 antibodies have been proven to be both effective and safe. In contrast, multispecific antibodies have not been studied as extensively, lacking comparable research and clinical data. The panel all agreed that easy targets are now gone so there is a need for more investigation into understanding the biological mechanisms that govern differential patient responses. The discussion rounded out with other forms of therapies such as RNA, DNA and biosimilars, and their challenges for adoption. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/cdc8745a-07f1-4b9b-975d-dc18465b3cf9/cell+therapy.png News - Top Trends in Immunotherapy – Festival of Biologics 2023 Recap - “we must pay attention to the secretome” Manufacturing of CAR T cells and biological approaches to increase the availability of CAR immunotherapies from Potential solutions for manufacture of CAR T cells in cancer immunotherapy https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/1698095042333-AJEFGDZS4DWWVHADWB6T/slide1.png News - Top Trends in Immunotherapy – Festival of Biologics 2023 Recap https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/1698095042296-QXUCI6BB1FNOQHMYARR5/slide2.png News - Top Trends in Immunotherapy – Festival of Biologics 2023 Recap https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/1698095043276-T3NGQKT9SHNZ3GBHINX0/slide3.png News - Top Trends in Immunotherapy – Festival of Biologics 2023 Recap https://www.partillion.com/news/partillion-seed-financing-announcement monthly 0.5 2023-09-26 https://www.partillion.com/news/new-study-identifies-genes-linked monthly 0.5 2023-09-26 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/f92659db-1983-4b85-9aef-54f02259e30c/RenderingofnanovialReneChangUniversityofWashington_hero.jpg News - News Update: Breakthrough Research in Immunoglobulin G (IgG) Production Featured in Nature Communications - Make it stand out A rendering of a plasma B cell secreting antibodies inside of a nanovial. (Image courtesy: Rene Chang/University of Washington). https://www.partillion.com/news/how-can-we-improve-cell-therapies monthly 0.5 2023-09-26 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/c4fae632-aeb2-47fd-8ea1-dc5a15eb5e8c/GEN_App_Icon_1024x1024.png News - Tracking Transcripts in Biologics and Cell Therapies - Make it stand out Read the original article at Genetic Engineering & Biotechnology News. https://www.partillion.com/news/nci-emerging-technologies-seminar-driving-next-generation-cancer-immunotherapeutic-design-using-partillion-technology monthly 0.5 2022-10-11 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/de13ec5f-8df5-4c08-828c-93b4664de374/logo-nih-cancer.jpg News - NCI Emerging Technologies Seminar - Driving Next Generation Cancer Immunotherapeutic Design Using Partillion Technology - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/news/new-preprint-association-of-molecular-signatures-with-antibody-secretion monthly 0.5 2022-10-11 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/8bd10cb2-7649-4e88-bab5-85621d26b4e0/SEC-Seq+Simple+Graphic+V4.png News - New Preprint: Association of Molecular Signatures with Antibody Secretion Using SEC-seq - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/6b755c77-5101-4d08-9dbb-edf9c8665693/SeattleChildrensLogo.png News - New Preprint: Association of Molecular Signatures with Antibody Secretion Using SEC-seq - Make it stand out Learn more about Richard James’ work at Seattle Children’s Hospital Here https://www.partillion.com/news/a-prologue-to-starting-a-biotech-company-during-the-pandemic monthly 0.5 2022-10-11 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/1651469596586-LUYLBNIKUQU53WKO2GLX/Moving%2Binto%2Blab.jpg News - A Prologue to Starting a Biotech Company During the Pandemic - Make it stand out Dec. 2020 - Moving into our lab space in the California Nanosystems Institute. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/59a49e00-d7ae-4444-8aa7-397fef6b4c8b/Lab+on+a+chip+to+lab+on+a+particle.JPG News - A Prologue to Starting a Biotech Company During the Pandemic - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/c83c7778-805d-4c65-90db-cb7e9c8bc0b7/Preview-Nature-paper-reductive+problem+solving.jpg News - A Prologue to Starting a Biotech Company During the Pandemic - Adding is favoured over subtracting in problem solving “Adding is favoured over subtracting in problem solving” Nature 2021 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/ab1143dc-f4f3-4b50-9096-8fe3928dd0b6/Nanovial+and+3D+printed.PNG News - A Prologue to Starting a Biotech Company During the Pandemic - Make it stand out Image: (Left) microscopy image of nanovials with cells inside and fluorescent signal from secreted proteins. (Right) 3D Printed Nanovial with a coffee bean inside to represent a cell. https://www.partillion.com/news/vyqqzq1s5ya513rwehvr4sfqauy6z4 monthly 0.5 2022-10-11 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/1651455783882-9E2QE9325LAE7459L7IP/biorxiv-2022-koo-TOC-thumbnail.PNG News - New Preprint: Sorting Single T Cells Based on Secreted Cytokines and Surface Markers - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/news/ucla-developed-technology-enables-single-cell-sorting-by-function monthly 0.5 2022-10-11 https://www.partillion.com/news/new-publication-acsnano-2022 monthly 0.5 2022-03-29 https://www.partillion.com/news/partillion-wins-top-new-product-award-at-slas-2022 monthly 0.5 2022-10-11 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/5972156c-44d8-42d3-83d8-ebbb21809fd1/New+Product+Award.png News - Partillion Wins Top New Product Award at SLAS 2022 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/news/new monthly 0.5 2022-03-29 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/1648344455060-AUIK7ZSG2L40MY93POAW/ACS+Nano+Lee+2021+News.jpg News - Published in ACS Nano: Recent Advances in Lab-on-a-particle Technology Unlocks Simplified Workflows for Single-cell Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/news/new-way-to-make-microparticles-could-accelerate-drug-development-production-of-new-cell-strains monthly 0.5 2022-10-10 https://www.partillion.com/news/slas2022 monthly 0.5 2022-10-11 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/ce32843f-50b3-4b01-9733-3240a38fc78e/Award-Finalist-Slas2022.jpg News - Partillion Selected as Finalist for Multiple Awards at SLAS 2022 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/news/blog-post-innovation-award-2020 monthly 0.5 2023-06-10 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/1629245088091-B2L5YBUMOQR4QM7YZYQ0/de_Rutte_SLAS2020_300w.jpg News - Partillion Co-Founder Awarded 2020 SLAS Innovation Award - Make it stand out https://www.slas.org/ https://www.partillion.com/news/category/conference monthly 0.5 https://www.partillion.com/news/category/Publications monthly 0.5 https://www.partillion.com/news/category/Announcement monthly 0.5 https://www.partillion.com/news/category/Partillion+in+the+Press monthly 0.5 https://www.partillion.com/news/category/Funding monthly 0.5 https://www.partillion.com/news/category/Talks monthly 0.5 https://www.partillion.com/news/category/Research monthly 0.5 https://www.partillion.com/news/category/Blog monthly 0.5 https://www.partillion.com/news/category/Presentations monthly 0.5 https://www.partillion.com/publications daily 0.75 2026-03-12 https://www.partillion.com/publications/2026-biorxiv-baghdasarian monthly 0.5 2026-03-12 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/25235bfc-8118-445f-8575-b21e23bb11dd/cell-cellseq.jpg Publications - Systematic mapping of emergent transcriptional states in interacting single-cell dyads by Cell-Cell-seq - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2025-scientific-reports-sakamoto monthly 0.5 2026-03-12 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/835d04c8-aa8b-4c04-bc96-61fd4b420ca8/Figure+5 Publications - Enhancing large particle recovery in high-throughput functional cell sorting through ΔBOP optimization - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2025-biorxiv-soemardy-tcr monthly 0.5 2026-01-28 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/420f44d8-f7cf-44c8-b7b7-590381ab7f36/Unconventional+TCR+Discovery+-+Fig+2.png Publications - A Nanovial-Based Platform for Functional Discovery of Antigen-Reactive TCRs from Unconventional T Cells - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2025-biorxiv-soemardy monthly 0.5 2025-08-15 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/9e75fff3-6efd-4aba-854b-420d2069b55e/biorxiv-CARTScreen_2025.png Publications - Screening of a pooled library of chimeric antigen receptor T cells based on secretory function - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2025-biorxiv-mellody monthly 0.5 2025-07-14 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/9549ed88-7b55-4d29-b6b5-561256384e60/two-cell_capped-NV.jpg Publications - Sealable capped nanovials for high-throughput screening of cell growth and function - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2025-biorxiv-olson monthly 0.5 2025-07-07 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/5b3c7545-4da8-4ca3-84b2-f663bd6c6c96/biorxiv-june-2025-results.jpg Publications - Functionalizing hydrogel nanovials with vesicles mimicking antigen-presenting vesicles and cancer exosomes improves T cell capture and activation - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2025-acsnano-kizerwetter monthly 0.5 2025-07-07 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/b7b2c0f5-5ae6-4fe8-90c5-fd572f995945/acs-nano-abstractImage-2025.png Publications - Specific Stimulation and Multiplex Secretion Analysis of T Cells Using a Suspendable Hydrogel Platform Enables Immunophenotyping at the Single-Cell Scale - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2025-eji-van-den-dijssel monthly 0.5 2025-07-07 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/53572515-832c-418e-96e6-040461e79e08/EIJ-2025-overviewFigure.jpg Publications - Linking Epitope-Specific T-Cell Receptors to IFNγ Secretion Using Nanovial Technology - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2025-natureprotocols-langerman monthly 0.5 2025-07-07 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/1ce82c65-0312-46ea-b343-7474db9fa1e4/sec-seq+overview Publications - Linking Single-Cell Transcriptomes with Secretion Using SEC-seq - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2025-labonachip-mellody monthly 0.5 2025-07-07 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/59d8634e-50ff-4a5e-9119-fb288732ee2f/Azide%2BBiotin.jpeg Publications - Multi-reactive Hydrogel Nanovials for Temporal Control of Secretion Capture from Antibody-Secreting Cells - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2024-biorxiv-challa monthly 0.5 2025-07-07 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/09a5524c-fffc-4f86-be5f-6e4e1d5675b0/Screenshot+2024-08-20+at+9.10.10%E2%80%AFAM.png Publications - Function-first Discovery of High Affinity Monoclonal Antibodies Using Nanovial-Based Plasma B Cell Screening - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2024-analyticalchem-ghosh monthly 0.5 2024-08-20 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/7ba25220-3fae-4476-a89f-978574d10f8e/Nanovials+AC+figure.jpeg Publications - Lab on a Particle Technologies - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2024-06-naturecomm-koo monthly 0.5 2024-06-13 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/a1624fd9-103e-4a25-8e7a-dd6400787a8c/2023-05+biorxiv+Koo+EV.JPG Publications - Optimizing Cell Therapy by Sorting Cells with High Extracellular Vesicle Secretion - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2024-labonachip-cbrandi monthly 0.5 2024-06-13 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/f1d5477d-7e82-4ef0-b60b-823513f052de/Screenshot+2024-05-29+at+9.58.40+PM.png Publications - On the Compatibility of Single-Cell Microcarriers (Nanovials) with Microfluidic Impedance Cytometry - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2024-pnas-dkoo monthly 0.5 2024-05-30 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/2710d92d-7db3-45b2-ba3c-c147de35c068/pnas.2320442121fig01.jpg Publications - Defining T cell receptor repertoires using nanovial-based binding and functional screening - Make it stand out Figure 1. Overview of high-throughput analysis and isolation of antigen-specific T cells followed by recovery of a single-cell TCR library. https://www.partillion.com/publications/2023-naturenanotech-udani monthly 0.5 2024-04-16 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/cc795260-3dc2-44d1-8286-a2b4cb6e81b2/Screenshot+2024-01-09+121227.jpg Publications - Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq - Make it stand out Workflow for SEC-seq. Cells are loaded, adhered and incubated in gelatin-coated nanovials functionalized with secretion capture antibodies. Secreted and captured proteins are labelled with oligo-barcoded detection antibodies. Nanovials loaded with single cells are then introduced into the 10x Chromium workflow for library preparation. Sequencing of the resulting libraries results in matched secretion and transcriptomics data for downstream analyses. Schematic partially created with BioRender.com. https://www.partillion.com/publications/2023-naturecomm-cheng monthly 0.5 2024-01-09 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/b6b5de93-78f4-4e04-8913-de8a147d892f/2023+Nature+Comm+Cheng+Fig+1+V2.jpg Publications - SEC-seq: Association of molecular signatures with antibody secretion in thousands of single human plasma cells - Make it stand out Workflow to link IgG secretion to surface markers and transcriptomes at the single-cell level. Human B cells are isolated from donors and expanded in a differentiation cocktail to promote differentiation into antibody-secreting cells. Cells are then loaded into a slurry of nanovials in a tube where they bind to antibodies on the nanovials for cell surface markers (CD27 or CD45). The loaded nanovials are incubated to accumulate secreted IgG on the surface via anti-IgG capture antibodies. Nanovials are then stained with fluorescent or oligo-barcoded anti-IgG, as well as viability dyes and other surface marker stains. Stained nanovials and associated cells are analyzed by flow cytometry (LSR II flow cytometer), imaging flow cytometry (ImageStream), or sorted (Nanocellect WOLF) for single-cell transcriptomics using the 10X Chromium system. Data linking IgG secretion with surface markers/functional dyes and transcriptomes at the single-cell level is acquired and analyzed. https://www.partillion.com/publications/2022-nature-miwa monthly 0.5 2023-07-09 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/706e4224-48a8-4b4e-8ce0-497ce9713f1a/Social+Image+2022-07+Nat+Micro+Nano+Miwa.jpg Publications - Single-cell sorting based on secreted products for functionally defined cell therapies - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/acsnano-2022-2 monthly 0.5 2023-12-12 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/6f67f67d-e60a-426c-a20e-63bc96a3bc8e/Webpage+Graphic+2023-03+ACS+Nano+de+Rutte.jpeg Publications - Suspendable Hydrogel Nanovials for Massively Parallel Single-Cell Functional Analysis and Sorting - Make it stand out Detection and sorting of antigen-specific antibody secreting cells. (A) Hybridomas or B cells loaded into nanovials secrete antibodies which are captured onto the nanovial surface via biotinylated capture antibodies. Captured IgG is then labeled with fluorescent antigen to assess specificity of the secreted IgG. (B) Fluorescence microscopy images reveal specific signal from binding to Alexa Fluor™ 647 conjugated hen egg lysozyme (HEL-647) on nanovials containing a hybridoma line (HyHEL-5) secreting IgG HEL while a cell line (9E10) secreting an off-target IgG results in no signal. (C) HyHel-5 hybridomas spiked into 9E10 hybridomas (CellTracker™ Blue) at a 1:25 ratio were assayed by fluorescence microscopy for HEL-specific signal before FACS sorting (Pre-Sort) and after sorting using a high HEL-AF647 gate (Post-Sort). A table showing the Pre-Sort and Post-Sort statistics is shown. (D) Using the index sorting function of the flow cytometer we sorted single hybridomas loaded onto nanovials and (i) demonstrate that RNA can be reverse transcribed and amplified from single cells loaded on nanovials at comparable rates to single cells sorted that were freely suspended. A gel band corresponding to the correct heavy chain amplicon length is observed. (ii) We additionally demonstrate that individual hybridomas can be expanded into a clonal colony directly from the nanovials following sorting. https://www.partillion.com/publications/2022-acsnano-lee monthly 0.5 2023-12-12 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/4c4c373e-5222-49d7-9fd1-6f1d60a5102b/Table+of+contents+figure.gif Publications - Scalable Fabrication and Use of 3D Structured Microparticles Spatially Functionalized with Biomolecules - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/publications/2021-slas-de-rutte monthly 0.5 2024-06-28 https://www.partillion.com/publications/2021-pre-du monthly 0.5 2023-07-09 https://www.partillion.com/publications/2020-sciadv-wu monthly 0.5 2023-07-09 https://www.partillion.com/publications/category/Cell+Line+Development monthly 0.5 https://www.partillion.com/publications/category/Workflow+Improvement monthly 0.5 https://www.partillion.com/publications/category/Applications monthly 0.5 https://www.partillion.com/publications/category/Technology monthly 0.5 https://www.partillion.com/publications/category/Theory monthly 0.5 https://www.partillion.com/publications/category/Review+Article monthly 0.5 https://www.partillion.com/publications/category/Extracellular+Vesicles monthly 0.5 https://www.partillion.com/publications/category/TCR+Discovery monthly 0.5 https://www.partillion.com/publications/category/SEC-Seq monthly 0.5 https://www.partillion.com/publications/category/Cytokine+Profiling monthly 0.5 https://www.partillion.com/publications/category/Cell+Therapy monthly 0.5 https://www.partillion.com/publications/category/Antibody+Discovery monthly 0.5 https://www.partillion.com/protocol-database daily 0.75 2024-01-04 https://www.partillion.com/protocol-database/mur-hyb monthly 0.5 2023-09-27 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/130ba214-18b9-4f00-b882-09834e84423b/thumbnail_MurineHybIgG+%28Small%29.jpg Protocol Database - Nanovial IgG Secretion Kit - Murine Hybridoma - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/protocol-database/byoc monthly 0.5 2024-01-04 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/08f5bd41-ce7f-4bad-a1d0-7213e0c777e1/thumbnail_byoc.png Protocol Database - Single-Cell Cytokine Profiling General Protocol (V2.0) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/protocol-database/adherent-cell monthly 0.5 2023-08-29 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/a0ba4e32-ed8a-4739-a110-6d7bc3e6ef14/thumbnail_adherentCell.png Protocol Database - Adherent Cell Secretion Protocol (V1.0 B) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/protocol-database/assay-cyt-01-4egzn-68d3y monthly 0.5 2024-01-04 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/f96cb037-695d-4ffc-bb5b-40ca6f19ae8b/Thumbnail+-+Protocol+-+Assay+-+Ab+Discovery+-+Vertical.jpg Protocol Database - Antigen Specific Antibody Secretion Protocol (V1.2) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/protocol-database/instrument-lsr-fortessa monthly 0.5 2024-01-04 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/6110bc13-1e61-4c32-b2e8-4f611d8999c8/Thumbnail+LSR+Fortessa+Gating+Protocol+V1.0_Outline+%28Small%29.jpg Protocol Database - BD LSR Fortessa Gating Protocol (V1.0) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/protocol-database/instrument-sh800 monthly 0.5 2024-01-04 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/b1476a58-5f19-40b1-aede-ac1031340c4d/Thumbnail+Sony+SH800+Gating+Protocol+V1.0_Outline+%28Small%29.jpg Protocol Database - SONY SH800 Gating Guide for Partillion Nanovials (V1.0) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/protocol-database/category/Instrument+Guide monthly 0.5 https://www.partillion.com/protocol-database/category/Assay+Protocols monthly 0.5 https://www.partillion.com/events daily 0.75 2026-02-02 https://www.partillion.com/events/cell-cell-symposium-2026 monthly 0.5 2026-02-12 https://www.partillion.com/events/cell-cell-symposium-2025 monthly 0.5 2025-02-13 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/fef568f4-4143-4ef4-942c-abaee34fc80d/cell-cell+Symposium.png Events - Cell-Cell Symposium https://www.partillion.com/events/agbt-2025-3a5xx monthly 0.5 2025-02-07 https://www.partillion.com/events/socal-flow-2025 monthly 0.5 2025-02-07 https://www.partillion.com/events/pegs-2025 monthly 0.5 2025-02-04 https://www.partillion.com/events/sefcig-2025 monthly 0.5 2025-02-04 https://www.partillion.com/events/immunology-2025 monthly 0.5 2025-02-11 https://www.partillion.com/events/agbt-2025 monthly 0.5 2025-02-04 https://www.partillion.com/events/slas-conference-2025 monthly 0.5 2025-01-27 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/0992a506-03c8-4ac6-bcf9-d6c5ebf68027/SLAS2025-Team.png Events - SLAS 2025 International Conference &amp; Exhibition - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/3ef55473-af62-4409-ade0-66f827f5114d/SLAS-Kira-Poster.png Events - SLAS 2025 International Conference &amp; Exhibition - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/86d27179-8465-4ab4-a932-cd377ea49c3f/Exhibitor+Linkedin.jpg Events - SLAS 2025 International Conference &amp; Exhibition - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/events/select-bio-2024 monthly 0.5 2024-11-04 https://www.partillion.com/events/metroflow-2024 monthly 0.5 2024-11-04 https://www.partillion.com/events/ucla-resources-day-2024 monthly 0.5 2024-10-24 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/32ef958c-16f1-4635-aaa0-f41a0c156f6c/Di+Carlo+Flyer+SR+Day+2024.png Events - UCLA Shared Resources Day - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/events/nih-research-festival-2024 monthly 0.5 2024-09-17 https://www.partillion.com/events/aet-conference-2024 monthly 0.5 2024-12-13 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/8e22e257-e893-4378-b75f-535fccd35f47/AET2024_partillion.png Events - Antibody Engineering &amp; Therapeutics 2024 - Meet us in San Diego for the Antibody Engineering & Therapeutics 2024. Poster Presentation: High-Throughput Cell Interaction Profiling for Precision Antibody Discovery, Katie Kershaw Booth 501 https://www.partillion.com/events/indian-ev-society-2024 monthly 0.5 2024-07-22 https://www.partillion.com/events/the-scientists-journal-club monthly 0.5 2024-04-02 https://www.partillion.com/events/festival-of-genomics-biodata monthly 0.5 2024-07-22 https://www.partillion.com/events/socal-flow-2024 monthly 0.5 2024-08-05 https://www.partillion.com/events/pegs-2024 monthly 0.5 2024-04-02 https://www.partillion.com/events/immunology-2024 monthly 0.5 2024-04-23 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/607bfb10-8eb7-459e-af82-17137f87f143/Slide2.png Events - Immunology 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.partillion.com/events/slas2024-presentation-3e4zz monthly 0.5 2024-01-08 https://www.partillion.com/events/slas2024-presentation monthly 0.5 2024-01-23 https://www.partillion.com/events/fully-human-antibody-discovery-using-nanovials-and-plasma-cells-from-atx-gktm-mice monthly 0.5 2023-11-29 https://www.partillion.com/events/accelerating-the-discovery-of-rare-antibodies-and-t-cell-receptors-tcrs-using-lab-on-a-particle-technology monthly 0.5 2024-01-08 https://www.partillion.com/events/aet-conference-2023 monthly 0.5 2024-07-22 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/251c9064-c5fd-418c-b6db-ec6ce2ee1dae/Screenshot+2023-11-01+at+1.12.35+PM.png Events - Antibody Engineering &amp; Therapeutics</a> 2023 - Booth #604 See you in San Diego! https://www.partillion.com/events/next-generation-nanovials-webinar-2023 monthly 0.5 2023-11-15 https://www.partillion.com/events/caltech-bioscience-industry-day-2023 monthly 0.5 2023-11-06 https://www.partillion.com/events/nanovials-and-single-cell-webinar-2023 monthly 0.5 2023-11-27 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/ac783343-be01-45e7-b4db-e620e42cef44/AbDiscoWeb.png Events - Nanovials and Single Cell Analysis: Fast-Tracking Antibody Discovery - Are you frustrated by time-consuming workflows that end up with hit-or-miss results? Don't miss our upcoming webinar to learn how to streamline your antibody discovery workflows using practical solutions. Learn how to profile antibody secreting cells at the single cell level using Nanovial technology and existing instrumentation Streamline the antibody discovery process by uncovering more diverse antibody repertoires in less time Enhance your existing hybridoma or B cell workflows to obtain more meaningful hits https://www.partillion.com/careers daily 0.75 2024-07-01 https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/d9459b78-0d8d-4c3c-badc-3bbb4e72b093/Dark+Blue+Background+Pattern+%28Compressed%29.jpg https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/a44aa55f-d1c1-4cff-8f4a-b8ef06b7acd5/2.png https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/f2d4aa9f-a3e1-4797-857f-2e96b355dccc/1.png https://images.squarespace-cdn.com/content/v1/5f84f789cca8e53428f1bc0f/ed08b425-593c-4d7b-b372-d655e54503a8/PXL_20230906_020200358+%281%29+%28Medium%29.jpg https://www.partillion.com/privacy-policy daily 0.75 2021-08-17 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